berkeley moynihan the surgical treatment of gastric and duodenal ulcers

Pantoprazole sodium and ondansetron hydrochloride are commonly prescribed for the treatment of gastric and duodenal ulcer associated with vomiting. Both the drugs having short biological half-life, so it leads frequent administration which may lead to patient incompliance. Further the pantoprazole Na is acid labile molecules and having irritation effect to stomach mucosa, so it needs to be given in the form of enteric formulation. While in case of ondansetron HCl have narrow therapeutic window in the stomach hence to prepare gastro-retentive formulation which offers advantages like better patient compliance and would lower the total cost of therapy. For the floating layer, influence of polymers and NaHCO3 with the application of 32 factorial design to optimization, for improving the sustain release of ondansetron HCl. It was prepared by wet granulation method and evaluated this layer using in vitro buoyancy and in vitro drug release study. For the enteric layer, influence of polymers and solvent system was preventing the drug release in the stomach environment with targeting at duodenal ulcers. It was prepared by intra-granulation method and evaluating by conducting in vitro study

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